Healthcare cannabis a feasible therapeutic remedy for Hepatitis C

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Abstract

Viral hepatitis B (HBV) and hepatitis C (HCV) pose a big overall health dilemma globally and if untreated, each viruses lead to serious liver harm resulting in liver cirrhosis and cancer. Whilst HBV has a vaccine, HCV has none at the moment. The danger of drug resistance, combined with the higher price of existing therapies, tends to make it a necessity for price-productive therapeutics to be found and created. The current surge in interest in Healthcare Cannabis has led to interest in evaluating and validating the therapeutic potentials of Cannabis and its metabolites against numerous illnesses like viruses. Preliminary screening of cannabidiol (CBD) revealed that CBD is active against HCV but not against HBV in vitro. CBD inhibited HCV replication by 86.four% at a single concentration of 10 μM with EC50 of three.163 μM in a dose-response assay. These findings recommend that CBD could be additional created and utilised therapeutically against HCV.

SUMMARY:

Cannabidiol exhibited in vitro activity against viral hepatitis C. Abbreviations Applied: CB2: Cannabis receptor two, CBD: Cannabidiol, DNA: Deoxyribonucleic acid, HBV: Hepatitis B virus, HCV: Hepatitis C virus, HIV/AIDS: Human immunodeficiency virus/acquired immune deficiency syndrome, HSC: Hepatic stellate cells, MTS: three-(four,five-dimethylthiazol-two-yl)-five-(three-carboxymethoxyphenyl)-two-(four-sulfophenyl)-2Htetrazolium, PCR: Polymerase chain reaction.

Copyright © 2018 Elsevier B.V. All rights reserved.

Supply:Pubmed

 

 

PMID: 28250664 PMCID: PMC5330095 DOI: 10.4103/0974-8490.199780

 

 

Lowe HI1, Toyang NJtwo, McLaughlin Wthree.

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