Elsevier

Available online 30 December 2020, 461864

Journal of Chromatography A

Highlights

Analytical techniques for detecting cannabinoids and terpenes in cannabis samples are explored

The issue of decarboxylation reaction of the cannabinoids in GC analysis are discussed

The advantages of LC analysis for cannabinoids determination are reported

High impact of the extraction procedures on terpenes content are addressed

Various GC separations are summarized

Abstract

The global Cannabis Sativa market, including essential oils, foods, personal-care products, and medical formulations has gained much attention over the last years due to the favorable regulatory framework. Undoubtedly, the enormous interest about cannabis cultivation mainly derives from the well-known pharmacological properties of cannabinoids and terpenes biosynthesized by the plants. In this review, the most recently used analytical methodologies for detecting both cannabinoids and terpenes are described. Well-established and innovative extraction protocols, and chromatographic separations, such as GC and HPLC, are reviewed highlighting their respective advantages and drawbacks. Lastly, GC × GC techniques are also reported for accurate identification and quantification of terpenes in complex cannabis matrices.

Keywords

Cannabis Sativa

hemp

marijuana

terpene

cannabinoid

GC

HPLC

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